Preoperative brain MRI features and occurrence of postoperative delirium

Delirium is a frequent complication after surgery with important negative outcomes for affected patients and society. However, it still largely unknown why some have predisposition delirium others not. To increase our understanding of the neural substrate postoperative delirium, we studied association between preoperative brain MRI features occurrence major surgery. A group 413 without dementia (Mean 72 years, SD: 5) was included in prospective observational two-center study design. The conducted at Charité Universitätsmedizin (Berlin, Germany) University Medical Center Utrecht (Utrecht, Netherlands). We measured volumes (total brain, gray matter, white matter), matter hyperintensity volume shape, infarcts cerebral perfusion, used logistic regression analysis adjusted age, sex, intracranial volume, center type Postoperative present total 70 (17%). Preoperative cortical increased risk although this did not reach statistical significance (OR (95%CI): 1.63 (0.84–3.18). Furthermore, found trend an more complex shape hyperintensities 0.97 (0.95–1.00)). volumes, perfusion were associated delirium. Our suggests that those may developing